PC945

Item no.	CS-0067758-100mg
Manufacturer	ChemScene
Amount	100mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	1931946-73-4
Similar products	1931946-73-4
Available
CAS	1931946-73-4
Purity	>98%
MWt	682.73
Formula	C38H37F3N6O3
Solubility	10 mM in DMSO
Clinical Information	No Development Reported
Pathway	Anti-infection; Metabolic Enzyme/Protease
Target	Fungal; Cytochrome P450
Biological Activity	PC945, a potent, long-acting antifungal triazole, possesses activity against a broad range of both azole-susceptible and azole-resistant strains of Aspergillus fumigatus. PC945 is also a potent, tightly binding inhibitor of A. fumigatus sterol 14alpha-demethylase activity, CYP51A and CYP51B, with IC₅₀s of 0.23 uM and 0.22 uM, respectively^[1]^[2]. In Vitro: PC945 is a triazole antifungal designed for administration via inhalation^[1]. PC945 exhibits the most potent antifungal activity on azole-susceptible strain NCPF2010 with the MIC value of 0.063?ug/mL^[2]. In Vivo: PC945 (0.56-14 ug/mouse; intranasal; daily for 7 days) substantially inhibits the incidence of rolling behavior^[1].
Research Area	Infection

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Amount: 100mg

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Delivery expected until 9/6/2024