PQCA

Item no.	CS-0065722-25mg
Manufacturer	ChemScene
Amount	25mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	1144504-35-7
Similar products	1144504-35-7
Available
CAS	1144504-35-7
Purity	>98%
MWt	388.42
Formula	C22H20N4O3
Solubility	DMSO : 10 mg/mL (ultrasonic; warming; heat to 80C)
Clinical Information	No Development Reported
Pathway	Neuronal Signaling; GPCR/G Protein
Target	mAChR; mAChR
Biological Activity	PQCA is a highly selective and potent muscarinic M1 receptor positive allosteric modulator. PQCA has an EC50 value of 49 nM and 135 nM on rhesus and human M1 receptor, respectively. PQCA is inactive for other muscarinic receptors. PQCA has potential to reduce the cognitive deficits associated with Alzheimer's disease. IC50 & Target: EC50: 49 nM (Rhesus M1 receptor) and 135 nM (Human M1 receptor) In Vivo: PQCA (3-30 mg/kg; oral administration; single- or pair-housed male rhesus monkeys) treatment attenuates the scopolamine deficits in PAL and CPT tasks. Blockade of muscarinic signaling by scopolamine produces significant impairments in both tasks.

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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