S55746

Item no.	CS-0065115-5mg
Manufacturer	ChemScene
Amount	5mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Similar products	1448584-12-0
Available
Alternative Names	BLC201
CAS	1448584-12-0
Purity	>98%
Formula	C43H42N4O6
MWt	710.82
Solubility	H2O : < 0.1 mg/mL (insoluble); DMSO : 50 mg/mL (70.34 mM; Need ultrasonic)
Clinical Information	Phase 1
Pathway	Apoptosis
Target	Bcl-2 Family
Biological Activity	S55746 (BLC201) is a potent, orally active and selective BCL-2 inhibitor, with a K_i of 1.3 nM and a K_d of 3.9 nM. S55746 (BLC201) has antitumor activity with low toxicity^[1]. IC50 & Target: Ki: 1.3 nM (BCL-2)^[1]. In Vitro: S55746 (0-1 uM) potently and selectively induces cell death^[1]. S55746 selectively induces apoptosis through BCL-2 inhibition in a BAX/BAK-dependent manner^[1]. In Vivo: S55746 is a highly efficacious and well-tolerated (even at doses up to 300 mg/kg) orally active BCL-2 inhibitor ^[1]. S55746 (20-100 mg/kg, p.o.) inhibits xenograft growth in RS4; 11 and Toledo models time- and dose-dependently^[1].

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