Comparison

Parsaclisib (hydrochloride)

Manufacturer ChemScene
Category
Type Molecules
Specific against other
Amount 25mg
Item no. CS-0062915-25mg
eClass 6.1 32169090
eClass 9.0 32169090
Available
Alias 1995889-48-9
Alternative Names
INCB050465 (hydrochloride)
CAS
1995889-48-9
Purity
>98%
MWt
469.34
Formula
C20H23Cl2FN6O2
Solubility
DMSO : 240 mg/mL (ultrasonic)
Clinical Information
No Development Reported
Pathway
PI3K/Akt/mTOR
Target
PI3K
Biological Activity
Parsaclisib hydrochloride (INCB050465 hydrochloride) is a potent, selective and orally active inhibitor of PI3Kdelta, with an IC50 of 1 nM at 1 mM ATP. Parsaclisib hydrochloride shows approximately 20000-fold selectivity over other PI3K class I isoforms. Parsaclisib hydrochloride can be used for the research of relapsed or refractory B-cell malignancies[1][2][3]. In Vitro: Parsaclisib (0.1-3000 nM; 4 d) inhibits proliferation of MCL and DLBCL cell lines[2].
Parsaclisib (0.1-1000 nM; 2 h) inhibits anti-IgM-induced pAKT (Ser473) in the Ramos Burkitt's lymphoma cell line, with an IC50 of 1 nM[2].
Parsaclisib inhibits the proliferation of human, dog, rat, and mouse primary B cells after activation of these receptors, with IC50s ranging from 0.2 to 1.7 nM[2].
In Vivo: Parsaclisib (10 mg/kg; oral gavage twice daily for 7-19 days) inhibits tumor growth in the BALB/c mice bearing the A20 murine lymphoma cells[2].
Parsaclisib (0.1-10 mg/kg; p.o. twice daily) slows Pfeiffer xenograft tumor growth in a dose-dependent manner. And Parsaclisib was well tolerated[2].
Parsaclisib (0.5-1 mg/kg; a single p.o.) inhibits pAKT (Ser473) in Pfeiffer subcutaneous mouse xenograft models[2].
Research Area
Cancer

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Amount: 25mg
Available: In stock
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