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Cyclo(Arg-Gly-Asp-D-Phe-Val) (TFA)

Cyclo(Arg-Gly-Asp-D-Phe-Val) (TFA)

Item no.	CS-0062738-1mg
Manufacturer	ChemScene
Amount	1mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Similar products	199807-33-5
Available
CAS	199807-33-5
Purity	>98%
Formula	C28H39F3N8O9
MWt	688.65
Solubility	10 mM in DMSO
Clinical Information	No Development Reported
Pathway	Cytoskeleton
Target	Integrin
Biological Activity	Cyclo(Arg-Gly-Asp-D-Phe-Val) (TFA) is an inhibitor of integrin alphavbeta3, with antitumor activity. IC50 & Target: alphavbeta3^[1] In Vitro: Cyclo(Arg-Gly-Asp-D-Phe-Val) (TFA) is an inhibitor of integrin alphavbeta3. Cyclo(Arg-Gly-Asp-D-Phe-Val) [c(RGDfV); 35 nM] induces disruption of leukemia cell migration and adhesion to leukemia osteoblasts in the 3D and 2D culture systems, affects the leukemia cell cycle and induces apoptosis in leukemia cells^[1].

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