SSE15206

1370046-40-4

C19H21N3O3S

DMSO : 150 mg/mL (403.82 mM; Need ultrasonic); H2O : < 0.1 mg/mL (insoluble)

Cell Cycle/DNA Damage; Cytoskeleton

SSE15206 is a microtubule polymerization inhibitor (GI₅₀ = 197 nM in HCT116 cells) that overcomes multidrug resistance. Causes aberrant mitosis resulting in G2/M arrest due to incomplete spindle formation in cancer cells^[1]. IC50 & Target: GI50: 197 nM (microtubule)^[1]. In Vitro: SSE15206 induces apoptosis in cells irrespective of MDR-1 overexpression cell lines (KB-V1, A2780-Pac-Res), highly resistant to paclitaxel cells (HCT116-Pac-Res) and parental cells at the concentration of 5 x and 10 x GI₅₀ values. To conclude, SSE15206 is able to overcome resistance to chemotherapeutic drugs such as paclitaxel in different cancer cell lines^[1].