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ARS-1630

ARS-1630

Item no.	CS-0035117-100mg
Manufacturer	ChemScene
Amount	100mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Similar products	1698055-86-5
Available
CAS	1698055-86-5
Purity	>98%
Formula	C21H17ClF2N4O2
MWt	430.84
Solubility	DMSO : >= 69 mg/mL (160.15 mM)
Clinical Information	No Development Reported
Pathway	GPCR/G Protein
Target	Ras
Biological Activity	ARS-1630, a less active enantiomer of ARS-1620, is a novel inhibitor of mutant K-ras G12C extracted from patent WO 2015054572 A1. IC50 & Target: K-Ras G12C^[1] In Vitro: KRAS^G12C is recently identified to be potentially druggable by allele-specific covalent targeting of Cys-12 in vicinity to an inducible allosteric switch II pocket (S-IIP). Success of this approach requires active cycling of KRAS^G12C between its active-GTP and inactive-GDP conformations as accessibility of the S-IIP is restricted only to the GDP-bound state. This strategy proves feasible for inhibiting mutant KRAS in vitro^[2].

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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