Corin

1808113-09-8

C26H28N4O2

H2O : < 0.1 mg/mL (insoluble); DMSO : 100 mg/mL (233.36 mM; Need ultrasonic)

Epigenetics; Epigenetics; Cell Cycle/DNA Damage

Corin is a dual inhibitor of histone lysine specific demethylase (LSD1) and histone deacetylase (HDAC), with a K_i(inact) of 110 nM for LSD1 and an IC₅₀ of 147 nM for HDAC1. IC50 & Target: IC50: 147 nM (HDAC1), Ki(inact): 110 nM (LSD1)^[1]. In Vitro: Corin is able to inhibit the deacetylation of semisynthetic, reconstituted nucleosomes by the CoREST ternary complex. Corin shows irreversible inhibition of HDAC1 activity. In Comparison to MS-275, corin appears to more potently (Corin EC₅₀ 95 nM vs. MS-275 EC₅₀ 420 nM) and efficaciously induce cellular H3K9 acetylation. Interestingly, Corin (1 uM) is non-toxic to primary human melanocytes in contrast to MS-275 (1 uM)^[1].