BI-6C9

Item no.	CS-0029592-10mg
Manufacturer	ChemScene
Amount	10mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	791835-21-7
Similar products	791835-21-7
Available
CAS	791835-21-7
Purity	>98%
MWt	471.59
Formula	C23H25N3O4S2
Solubility	DMSO : 250 mg/mL (530.12 mM; Need ultrasonic)
Clinical Information	No Development Reported
Pathway	Metabolic Enzyme/Protease
Target	Mitochondrial Metabolism
Biological Activity	BI-6C9 is a highly specific BH3 interacting domain (Bid) inhibitor, which prevents mitochondrial outer membrane potential (MOMP) and mitochondrial fission, and protects the cells from mitochondrial apoptosis inducing factor (AIF) release and caspase-independent cell death in neurons^[1]. In Vitro: HT-22 cells shows reduction of cell viability around 4.5 h after Glutamate (3 mM and 5 mM) treatment. BI-6c9 (10 uM; 18 hours) significantly attenuates the loss of cell viability after Glutamate excitotoxicity^[1].
Research Area	Neurological Disease

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