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PROTAC BET Degrader-1

PROTAC BET Degrader-1

Item no.	CS-0028483-10mg
Manufacturer	ChemScene
Amount	10mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Similar products	2093386-22-0
Available
CAS	2093386-22-0
Purity	>98%
Formula	C44H45N11O9
MWt	871.90
Solubility	DMSO : >= 50 mg/mL (57.35 mM)
Clinical Information	No Development Reported
Pathway	Epigenetics; PROTAC
Target	Epigenetic Reader Domain; PROTAC
Biological Activity	PROTAC BET Degrader-1 is a potent BET degrader based on PROTAC, decreasing BRD2, BRD3, and BRD4 protein levels at low concentration. IC50 & Target: BET^[1] In Vitro: PROTAC BET Degrader-1 (Compound 9) is a potent BET degrader based on PROTAC, decreases the level of BRD2, BRD3, and BRD4 proteins in RS4; 11 cells at 3-10 nM, and inhibits the growth of this cell line with an IC₅₀ of 4.3 nM, and 45.5 nM for MOLM-13 cells^[1].

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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