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Dazoxiben

Dazoxiben

Item no.	CS-0024780-25mg
Manufacturer	ChemScene
Amount	25mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	74226-22-5
Similar products	74226-22-5
Available
CAS	74226-22-5
Purity	>98%
MWt	268.70
Formula	C12H13ClN2O3
Solubility	DMSO : 62.5 mg/mL (232.60 mM; Need ultrasonic)
Clinical Information	No Development Reported
Pathway	GPCR/G Protein
Target	Prostaglandin Receptor
Biological Activity	Dazoxiben is a potent and orally active thromboxane (TX) synthase inhibitor^[1]. IC50 & Target: Thromboxane (TX) synthase^[1] In Vitro: Dazoxiben inhibits TXB2 production in clotting human whole blood with an IC₅₀ of 0.3 uM and causes parallel enhancement of PGE2 greater than PGF2 alpha greater than 6-keto-PGF1 alpha production^[1]. Dazoxiben inhibits TXB2 production in rat kidney glomeruli with an IC₅₀ of 1.60 uM) than in rat whole blood (IC₅₀= 0.32uM), and is not associated with changes in PGE2, PGF2 alpha and 6-keto-PGF1 alpha production^[1]. In Vivo: Dazoxiben (intraperitoneal administration; 100 ug/kg) produces a marked prolongation of the tail bleeding time with 96.8 +/- 10.8 secs^[2].
Research Area	Inflammation/Immunology

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Amount: 25mg

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Delivery expected until 9/6/2024

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