ML311

Item no.	CS-0021886-50mg
Manufacturer	ChemScene
Amount	50mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Similar products	315698-17-0
Available
CAS	315698-17-0
Purity	>98%
Formula	C23H24F3N3O
MWt	415.45
Solubility	DMSO : 67.5 mg/mL (162.47 mM; Need ultrasonic)
Clinical Information	No Development Reported
Pathway	Apoptosis
Target	Bcl-2 Family
Biological Activity	ML311 is a potent and selective inhibitor of the Mcl-1/Bim interaction. IC50 & Target: Mcl-1/Bim^[1]. In Vitro: ML311 potently halts viability of several types of Mcl-1 primed cells, including MCL-1-1780 (EC₅₀=0.31 uM), DHL-6 (EC₅₀=3.3 uM), and NCI-H929 (EC₅₀=1.6 uM), with generally high maximal effect (>80%). ML311 also displays activity in a leukemia-derived cell line particularly reliant upon Bcl-2 function (Bcl2-1863, EC₅₀=1.1 uM). ML311 has strong growth inhibitory effects in many cell lines, with GI₅₀<900 nM for nine cell types (RPMI-8226, SR, NCI-H322M, NCI-H60, HCC-2998, KM12, SF-295, U251, PC-3 cell lines), and <2 uM for 14 additional types^[1].

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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