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eIF4A3-IN-1

eIF4A3-IN-1

Item no.	CS-0021616-100mg
Manufacturer	ChemScene
Amount	100mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	2095486-67-0
Similar products	2095486-67-0
Available
CAS	2095486-67-0
Purity	>98%
MWt	588.88
Formula	C29H23BrClN5O2
Solubility	DMSO : 200 mg/mL (339.63 mM; Need ultrasonic)
Clinical Information	No Development Reported
Pathway	Cell Cycle/DNA Damage; Autophagy
Target	Eukaryotic Initiation Factor (eIF); Autophagy
Biological Activity	eIF4A3-IN-1 (compound 53a) is a selective eukaryotic initiation factor 4A3 (eIF4A3) inhibitor (IC₅₀=0.26 uM; K_d=0.043 uM), which binds to a non-ATP binding site of eIF4A3 and shows significant cellular nonsense-mediated RNA decay (NMD) inhibition at 10 and 3 uM and can be as a probe for further study of eIF4A3, the exon junction complex (EJC), and NMD^[1]. IC50 & Target: IC50: 0.2 uM (eIF4A3)^[1] Kd: 0.043 uM (eIF4A3)^[1]
Research Area	Cancer

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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