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MMAF (sodium)

MMAF (sodium)

Item no.	CS-0021397-2mg
Manufacturer	ChemScene
Amount	2mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	1799706-65-2
Similar products	1799706-65-2
Available
Alternative Names	Monomethylauristatin F (sodium)
CAS	1799706-65-2
Purity	>98%
MWt	753.94
Formula	C39H64N5NaO8
Solubility	DMSO : >= 200 mg/mL (265.27 mM)
Clinical Information	No Development Reported
Pathway	Cell Cycle/DNA Damage; Cytoskeleton; Antibody-drug Conjugate/ADC Related
Target	Microtubule/Tubulin; Microtubule/Tubulin; ADC Cytotoxin
Biological Activity	MMAF sodium (Monomethylauristatin F sodium) is a potent tubulin polymerization inhibitor and is used as a antitumor agent. MMAF sodium (Monomethylauristatin F sodium) is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) such as Vorsetuzumab mafodotin and SGN-CD19A^[1]^[2]^[3]. In Vitro: MMAF inhibits anaplastic large cell lymphoma Karpas 299, breast carcinoma H3396, renal cell carcinoma 786-O and Caki-1 cells with IC₅₀s of 119, 105, 257 and 200 nM in vitro cytotoxicity assay^[4].
Research Area	Cancer

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Amount: 2mg

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Delivery expected until 9/6/2024