STAT3-IN-1

2059952-75-7

475.53

DMSO : 125 mg/mL (262.86 mM; Need ultrasonic)

Apoptosis; JAK/STAT Signaling; Stem Cell/Wnt

STAT3-IN-1 (compound 7d) is an excellent, selective and orally active STAT3 inhibitor, with IC₅₀ values of 1.82 uM and 2.14 uM in HT29 and MDA-MB 231 cells, respectively. STAT3-IN-1 (compound 7d) induces tumor apoptosis^[1]. IC50 & Target: IC50: 1.82 uM (STAT3 in HT29 cells), 2.14 uM (STAT3 in MDA-MB 231 cells)^[1]. In Vitro: STAT3-IN-1 (compound 7d: 0-10 uM, 48 h) inhibits the STAT3 acetylation at lysine 685 and affected its specific genes expressions^[1].
STAT3-IN-1 (compound 7d: 0-10 uM, 48 h) induces tumor cells apoptosis in MDA-MB-231 cells^[1]. In Vivo: STAT3-IN-1 (compound 7d: 10, 20 mg/kg, two weeks) arrests tumor growth with low toxicity in mouse-xenograft model^[1].