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Tyrosine kinase-IN-1

Tyrosine kinase-IN-1

Item no.	CS-0018466-100mg
Manufacturer	ChemScene
Amount	100mg
Category	Oncology Reagents & Chemicals Molecules By Organ Colorectal Cancer
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	705946-27-6
Similar products	705946-27-6
Available
CAS	705946-27-6
Purity	>98%
MWt	445.53
Formula	C26H28FN5O
Solubility	DMSO : >= 62.5 mg/mL (140.28 mM)
Clinical Information	No Development Reported
Pathway	Protein Tyrosine Kinase/RTK; Protein Tyrosine Kinase/RTK; Protein Tyrosine Kinase/RTK
Target	VEGFR; PDGFR; FGFR
Biological Activity	Tyrosine kinase-IN-1 is a multi-targeted tyrosine kinase inhibitor with IC₅₀s of 4, 20, 4, 2 nM for KDR, Flt-1, FGFR1 and PDGFRalpha, respectively. IC50 & Target: IC50: 4 nM (KDR), 20 nM (Flt-1), 4 nM (FGFR1), 2 nM (PDGFRalpha)^[1] In Vitro: Tyrosine kinase-IN-1 is from reference (compound 8K)^[1]. In Vivo: Tyrosine kinase-IN-1 shows a reasonable PK profile (AUC(_0-?)=1.9, t_1/2=4.6 h). It has a favorable oral bioavailability (F=63%) in rats^[1].
Research Area	Cardiovascular Disease

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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