ML-210

Item no.	CS-0017911-10mg
Manufacturer	ChemScene
Amount	10mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	1360705-96-9
Similar products	1360705-96-9
Available
CAS	1360705-96-9
Purity	>98%
MWt	475.32
Formula	C22H20Cl2N4O4
Solubility	DMSO : 25 mg/mL (52.60 mM; Need ultrasonic)
Clinical Information	No Development Reported
Pathway	Apoptosis; Metabolic Enzyme/Protease
Target	Ferroptosis; Glutathione Peroxidase
Biological Activity	ML-210 is a selective and covalent glutathione peroxidase 4 (GPX4) inhibitor with an EC₅₀ of 30 nM. ML-210 binds the GPX4 selenocysteine residue. ML-210 has anti-cancer activity^[1]^[2]. IC50 & Target: Glutathione Peroxidase 4 (GPX4)^[1] In Vitro: ML-210 exhibits cell-killing activity across a panel of 821 cancer cell lines (WM88, LOX-IMVI, CJM, U257, CAKI2, A498, HT1080, MC38, PANC02). ML-210 is a prodrug that requires cellular activation to bind GPX4^[1]. ML-210 has IC₅₀s of 71 nM, 272 nM and 107nM for BJeLR (HRAS_V12), BJeH-LT (without HRAS_V12) and DRD cell lines, respectively^[2].
Research Area	Cancer

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

Request safety datasheet

Simple Order Order Subscription

Amount: 10mg

available

Delivery expected until 9/6/2024

Express Delivery: Save 8 days

Compare

Add to wishlist

Recommend by mail