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T6167923

T6167923

Item no.	CS-0016557-50mg
Manufacturer	ChemScene
Amount	50mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	2437475-16-4
Similar products	2437475-16-4
Available
CAS	2437475-16-4
Purity	>98%
MWt	458.39
Formula	C17H20BrN3O3S2
Solubility	DMSO : 250 mg/mL (545.39 mM; Need ultrasonic)
Clinical Information	No Development Reported
Pathway	Immunology/Inflammation
Target	MyD88
Biological Activity	T6167923 is a potent and selective inhibitor of MyD88-dependent signaling pathways. T6167923 directly binds to Toll/IL1 receptor (TIR) domain of MyD88 and disrupts MyD88 homodimeric formation. T6167923 inhibits NF-kappaB driven Staphylococcus enterotoxin AP (SEAP) activity, and improves anti-inflammatory activity with an ₅₀ of 2.7 ?uM, 2.9 uM, 2.66 uM and 2.66 uM for IFN-gamma, IL-1beta, IL-6 and TNF-alpha, respectively^[1]. IC50 & Target: MyD88^[1]
Research Area	Inflammation/Immunology

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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