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NSC-87877

NSC-87877

Item no.	CS-0014260-5mg
Manufacturer	ChemScene
Amount	5mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	56990-57-9
Similar products	56990-57-9
Available
CAS	56990-57-9
Purity	>98%
MWt	459.45
Formula	C19H13N3O7S2
Solubility	DMSO : 5 mg/mL (10.88 mM; Need ultrasonic)
Clinical Information	No Development Reported
Pathway	Apoptosis; Metabolic Enzyme/Protease
Target	Apoptosis; Phosphatase
Biological Activity	NSC-87877 is a potent inhibitor of Shp2 and Shp1 protein tyrosine phosphatases (SH-PTP2 and SH-PTP1), with IC₅₀ values of 0.318 uM, 0.355 uM shp2 and shp1, respectively^[1]. NSC-87877 also inhibits dual-specificity phosphatase 26 (DUSP26)^[2]. IC50 & Target: IC50: 0.318 uM (shp2), 0.355 uM (shp1)^[1]. In Vitro: NSC-87877 (0-0.5 uM, 5 days) inhibits DUSP26 function in NB cell lines^[3]. NSC-87877 (0-0.5 uM, 5 days) results in increased p53 phosphorylation (Ser37 and Ser46) and activation^[3]. In Vivo: NSC-87877 (30?mg/kg, IP once daily for 15 days) possesses excellent anti- neuroblastoma activity^[3].
Research Area	Others

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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