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Tolonidine

Tolonidine

Item no.	CS-0013841-5mg
Manufacturer	ChemScene
Amount	5mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	4201-22-3
Similar products	4201-22-3
Available
CAS	4201-22-3
Purity	>98%
MWt	209.68
Formula	C10H12ClN3
Solubility	10 mM in DMSO
Clinical Information	No Development Reported
Pathway	Others
Target	Others
Biological Activity	Tolonidine is a derivative of imidazoline. Tolonidine is orally active and has been shown to possess hypotensive and antihypertensive properties^[1]. In Vivo: In the anesthetized dog, tolonidine administered i.v. decreases the amplitude of ventricular contractions, reduces aortic blood flow and increases peripheral vascular resistances^[1]. In the bivagotomized pithed rat, tolonidine induces a long-lasting increase in blood pressure with no secondary hypotension, thus suggesting peripheral sympathomimetic properties^[1].
Research Area	Cardiovascular Disease

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