Sodium diatrizoate

737-31-5

635.90

DMSO : 100 mg/mL (157.26 mM; Need ultrasonic); H2O : >= 50 mg/mL (78.63 mM)

Others

Sodium diatrizoate (Diatrizoic acid sodium salt) is an iodinated radiocontrast agent and has the potential for radiographic imaging of the airways. Sodium diatrizoate induces mitochondrial turnover and oxidative stress, and activating apoptosis by dysregulating calcium^[1][2]. In Vitro: HK-2 cells are exposed to 0-30 mg I/mL Sodium diatrizoate (Diatrizoic acid sodium salt) or vehicle for 2-24 h. MTT and trypan blue exclusion indicate a decrease in mitochondrial and cell viability within 2 and 24 h, respectively^[2].
In Vivo: Sodium diatrizoate is an iodinated radiocontrast agent. Histological examination of rat lung tissue shows no acute toxicity or inflammation after insufflation of Sodium diatrizoate nanoparticle agglomerates. Sodium diatrizoate nanoparticle agglomerates offers a promising radiocontrast agent for safe and effective lung visualization^[1].