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Halazone

Halazone

Item no.	CS-0013119-100mg
Manufacturer	ChemScene
Amount	100mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	80-13-7
Similar products	80-13-7
Available
CAS	80-13-7
Purity	>98%
MWt	270.09
Formula	C7H5Cl2NO4S
Solubility	10 mM in DMSO
Clinical Information	Launched
Pathway	Metabolic Enzyme/Protease; Anti-infection; Membrane Transporter/Ion Channel
Target	Carbonic Anhydrase; Bacterial; Sodium Channel
Biological Activity	Halazone is an atypical antimicrobial sulfonamide derivative and a carbonic anhydrase II inhibitor with a K_d value of 1.45 uM. Halazone protects sodium channels from inactivation. Halazone is widely used for disinfection of drinking water^[1]^[2]. In Vitro: Halazone is chemically closely related to Chloramine-T, the nitrogen atom is linked with two instead of one chlorine atom and, certainly more important here, a methyl group is replaced by a carboxyl group. The effect of Halazone on the sodium current is studied in voltage-clamped single nerve fibers of the frog. The oxidant Halazone drastically inhibits inactivation^[1].
Research Area	Infection

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