Triprolidine (hydrochloride monohydrate)

6138-79-0

332.87

10 mM in DMSO

Immunology/Inflammation; GPCR/G Protein; Neuronal Signaling

Triprolidine hydrochloride monohydrate is an orally active, cell-permeable and first-generation histamine H1 antagonist^[1]. Triprolidine hydrochloride monohydrate is an antihistamine and can be used in allergic rhinitis; asthma; and urticaria^[2]. IC50 & Target: IC50: histamine H1 receptor^[1] In Vivo: Triprolidine (intraseptal infusion; 0.5 uM in 0.5 ul; 30, 60, and 180 min after tetanus) had no significant effects on the baseline fEPSPs, however, it is followed by a smaller Long-term potentiation (LTP) induced during walking (173% of the baseline at 60 min) compared with saline infusion (208% at 60 min) in rats^[2].