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S-Adenosyl-L-methionine (disulfate tosylate)

S-Adenosyl-L-methionine (disulfate tosylate)

Item no.	HY-W017770-500mg
Manufacturer	MedChem Express
CASRN	97540-22-2
Amount	500 mg
Quantity options	100 mg 10 mM/1 mL 250 mg 500 mg 50 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	98.80
Formula	C22H34N6O16S4
Citations	Pharmacol Res. 2024 Sep 16:107420. Biochem Pharmacol. 2023 Dec 6:219:115967. bioRxiv. 2023 Jun 1. Epigenetics Chromatin. 2021 Dec 4;14(1):52. Int Immunopharmacol. 2021 Mar 22;95:107545. J Agric Food Chem. 2021 Jul 30. Research Square Preprint. 2020 Aug. Research Square Preprint. 2021 Jun. J Cell Physiol. 2024 Oct 6:e31452. Molecules. 2023 Apr 11, 28(8), 3375. J Pharm Biomed Anal. 2024 Jan 20, 115991. [1]Lu SC, et al. S-adenosylmethionine in liver health, injury, and cancer. Physiol Rev. 2012 Oct;92(4):1515-42. [2]Bressa GM. S-adenosyl-l-methionine (SAMe) as antidepressant: meta-analysis of clinical studies. Acta Neurol Scand Suppl. 1994;154:7-14. [3]Najm WI, et al. S-adenosyl methionine (SAMe) versus celecoxib for the treatment of osteoarthritis symptoms: a double-blind cross-over trial. [ISRCTN36233495]. BMC Musculoskelet Disord. 2004 Feb 26;5:6. [4]Mosca L, et al. Effects of S‑adenosyl‑L‑methionine on the invasion and migration of head and neck squamous cancer cells and analysis of the underlying mechanisms. Int J Oncol. 2020 May;56(5):1212-1224. [5]Ham MS, et al. S-adenosyl methionine specifically protects the anticancer effect of 5-FU via DNMTs expression in human A549 lung cancer cells. Mol Clin Oncol. 2013 Mar;1(2):373-378. [6]Ornoy A, et al. S-adenosyl methionine prevents ASD like behaviors triggered by early postnatal valproic acid exposure in very young mice. Neurotoxicol Teratol. 2019 Jan-Feb;71:64-74. [7]Dhediya RM, et al. Evaluation of antiepileptic effect of S-adenosyl methionine and its role in memory impairment in pentylenetetrazole-induced kindling model in rats. Epilepsy Behav. 2016 Aug;61:153-157.
Smiles	N[C@@H](CC[S+](C[C@@H]1[C@H]([C@H]([C@H](N2C=NC3=C2N=CN=C3N)O1)O)O)C)C(O)=O.O=S(O)([O-])=O.O=S(O)(O)=O.OS(=O)(C4=CC=C(C)C=C4)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Ademetionine (disulfate tosylate), S-Adenosyl methionine (disulfate tosylate), AdoMet (disulfate tosylate)
Shipping condition	Cool pack
Available
Manufacturer - Type	Natural Products
Manufacturer - Applications	Neuroscience-Neuromodulation
Manufacturer - Targets	Apoptosis; Endogenous Metabolite
Shipping Temperature	Blue Ice
Storage Conditions	-20°C (Powder, sealed storage, away from moisture)
Molecular Weight	766.80
Product Description	S-Adenosyl-L-methionine disulfate tosylate is the disulfate tosylate form of S-Adenosyl-L-methionine (HY-B0617). S-Adenosyl-L-methionine is an orally active methyl group donor. S-Adenosyl-L-methionine is a dietary supplement with potent antidepressant effects. S-Adenosyl-L-methionine also has anti‑proliferative, pro‑apoptotic and anti‑metastatic roles in cancers. S-Adenosyl-L-methionine has the potential for, cancer, liver disease and osteoarthritis research[1][2][3].
Manufacturer - Research Area	Neurological Disease; Cancer
Solubility	DMSO : ≥ 50 mg/mL\|H2O : 33.33 mg/mL (ultrasonic)
Manufacturer - Pathway	Apoptosis; Metabolic Enzyme/Protease
Isoform	Human Endogenous Metabolite
Clinical information	Launched

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HY-W017770-500mg-safety-datasheet.pdf