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ARS-1620

ARS-1620

Item no.	HY-U00418-200mg
Manufacturer	MedChem Express
CASRN	1698055-85-4
Amount	200 mg
Quantity options	100 mg 10mM/1mL 10 mg 200 mg 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.62
Citations	[1]Janes MR, et al. Targeting KRAS Mutant Cancers with a Covalent G12C-Specific Inhibitor. Cell. 2018 Jan 25;172(3):578-589.e17.
Smiles	C=CC(N1CCN(C2=C3C=C(Cl)[C@]([C@]4=C(O)C=CC=C4F)=C(F)C3=NC=N2)CC1)=O.[S]
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	1698055-85-4
Available
Product Description	ARS-1620 is an atropisomeric selective KRASG12C inhibitor with desirable pharmacokinetics.
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-Kinase/protease
MolecularWeight	430.84
Clinical_Information	No Development Reported
Manufacturers Research Area	Cancer
Solubility	DMSO : 125 mg/mL (ultrasonic)\|H2O : 11 mg/mL (ultrasonic; adjust pH to 3 with HCl)
Manufacturers Target	Ras
Isoform	K-Ras
Pathway	GPCR/G Protein; MAPK/ERK Pathway

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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HY-U00418-200mg-safety-datasheet.pdf