Comparison

CI-949 European Partner

Item no. HY-U00364-5mg
Manufacturer MedChem Express
CASRN 104961-19-5
Amount 5 mg
Quantity options 100 mg 10 mg 1 ea 1 mg 20 mg 5 mg
Category
Type Inhibitors
Specific against other
Citations [1]Conroy MC, et al. Inhibition of histamine, leukotriene C4/D4, and thromboxane B2 release from human leukocytes and human chopped lung mast cells by the allergic mediator release inhibitor, CI-949. J Allergy Clin Immunol. 1990 Dec;86(6 Pt 1):902-8.
[2]Adolphson RL, et al. CI-949: a new, potential antiallergy compound inhibits antigen-induced allergic reactions in guinea-pigs in vitro and in vivo. Pulm Pharmacol. 1990;3(4):203-8.
Smiles O=C(C(N1C2=CC=CC=C2)=C(OC(C)C)C3=C1C=CC(OC)=C3)NC4=NN=NN4
ECLASS 10.1 32160490
ECLASS 11.0 32160490
UNSPSC 12000000
Alias 104961-19-5
Shipping condition Room temperature
Available
Manufacturer - Type
Reference compound
Manufacturer - Applications
Metabolism-protein/nucleotide metabolism
Manufacturer - Targets
Histamine Receptor; Leukotriene Receptor; Prostaglandin Receptor
Shipping Temperature
Room Temperature
Molecular Weight
392.41
Product Description
CI-949 is an allergic mediator release inhibitor, which inhibits histamine, leukotriene C4/D4 (LTC4/LTD4), and thromboxane B2 (TXB2) release with IC50s of 11.4 μM, 0.5 μM and 0.1 μM, respectively.
Manufacturer - Research Area
Inflammation/Immunology; Endocrinology
Solubility
10 mM in DMSO
Manufacturer - Pathway
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Isoform
LTC4/CysLT2; LTD4/CysLT1; TXB2
Clinical information
Phase 2

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 5 mg
Available: In stock
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