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Bradykinin

Bradykinin

Item no.	HY-P0206-100mg
Manufacturer	MedChem Express
CASRN	58-82-2
Amount	100 mg
Quantity options	100 mg 10mM*1 mL 10 mg 1 mg 25 mg 50 mg 5 mg
Category	Oncology Neuroscience Metabolism Diabetes Glucose Homeostasis Cholesterol & Lipid Metabolism Neural Signaling Peptides & Proteins Enzymes Other Fatty Acid Enzymes Peptides By Organ Uterine, Ovarian & Cervical Cancer
Type	Peptides
Specific against	other
Purity	99.92
Formula	C50H73N15O11
Citations	[1]Hornig B, et al. Role of bradykinin in mediating vascular effects of angiotensin-converting enzyme inhibitors inhumans. Circulation. 1997 Mar 4;95(5):1115-8.<br/>[2]Wang G, et al. Bradykinin stimulates IL-6 production and cell invasion in colorectal cancer cells. Oncol Rep. 2014 Oct;32(4):1709-14.<br/>[3]Dong R, et al. Exogenous Bradykinin Inhibits Tissue Factor Induction and Deep Vein Thrombosis via Activating the eNOS/Phosphoinositide 3-Kinase/Akt Signaling Pathway. Cell Physiol Biochem. 2015;37(4):1592-606.<br/>[4]Uchida S, et al. Afferent fibers involved in the bradykinin-induced cardiovascular reflexes from the ovary in rats. Auton Neurosci. 2015 Dec;193:57-62.<br/>[5]Liu LT, et al. Effect of vascular bradykinin on pancreatic microcirculation and hemorheology in rats with severe acute pancreatitis. Eur Rev Med Pharmacol Sci. 2015;19(14):2646-50.
Smiles	O=C(N1[C@@H](CCC1)C(NCC(N[C@H](C(N[C@@H](CO)C(N2[C@@H](CCC2)C(N[C@H](C(N[C@H](C(O)=O)CCCNC(N)=N)=O)CC3=CC=CC=C3)=O)=O)=O)CC4=CC=CC=C4)=O)=O)[C@H]5N(CCC5)C([C@@H](N)CCCNC(N)=N)=O
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	58-82-2
Available
Product Description	Bradykinin is an effective endothelium-dependent vasodilator that can lower blood pressure. Bradykinin can induce contraction of bronchial and intestinal non-vascular smooth muscle, increase vascular permeability, and participate in the mechanism of pain[1][2][3][4][5].
StorageTemperature	-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Shipping	Blue Ice
Manufacturers Applications	COVID-19-immunoregulation
MolecularWeight	1060.21
Clinical Information	Phase 4
Manufacturers Research Area	Cardiovascular Disease; Endocrinology
Solubility	10 mM in DMSO\|H2O : ≥ 100 mg/mL
Target	Bradykinin Receptor; Endogenous Metabolite; Ser/Thr Protease
Manufacturers Target	Bradykinin Receptor; Endogenous Metabolite; Ser/Thr Protease
Isoform	Bradykinin B2 Receptor (B2R); Human Endogenous Metabolite
Manufacturers Pathway	GPCR/G Protein; Metabolic Enzyme/Protease
Manufacturers Product type	Peptides

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HY-P0206-100mg-safety-datasheet.pdf