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TAK-448 (acetate)

TAK-448 (acetate)

Item no.	HY-P0076A-5mg
Manufacturer	MedChem Express
CASRN	1470374-22-1
Amount	5 mg
Quantity options	10mM*1 mL 1 mg 5 mg
Category	Peptides & Proteins Peptides
Type	Peptides
Specific against	other
Purity	98.87
Formula	C60H84N16O16
Citations	[1]Nishizawa N, et al. Design and Synthesis of an Investigational Nonapeptide KISS1 Receptor (KISS1R) Agonist, Ac-d-Tyr-Hydroxyproline (Hyp)-Asn-Thr-Phe-azaGly-Leu-Arg(Me)-Trp-NH2 (TAK-448), with Highly PotentTestosterone-Suppressive Activity and Excellent Water Solubility. J Med Chem. 2016 Oct 13;59(19):8804-8811.<br>[2]Ishikawa K,et al. Usefulness of pharmacokinetic/efficacy analysis of an investigational kisspeptin analog, TAK-448, in quantitatively evaluating anti-tumor growth effect in the rat VCaP androgen-sensitiveprostate cancer model. Eur J Pharmacol. 2018 Jun 5;828:126-134.
Smiles	O=C(N)[C@H](CC1=CNC2=CC=CC=C12)NC([C@H](CCCNC(NC)=N)NC([C@H](CC(C)C)NC(NNC([C@H](CC3=CC=CC=C3)NC([C@H]([C@H](O)C)NC([C@H](CC(N)=O)NC([C@H]4N(C([C@@H](CC5=CC=C(C=C5)O)NC(C)=O)=O)C[C@H](O)C4)=O)=O)=O)=O)=O)=O)=O.OC(C)=O
ECLASS 5.1	34160400
ECLASS 6.1	34160400
ECLASS 8.0	32160409
ECLASS 9.0	32160409
ECLASS 10.0.1	32160409
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	MVT-602 (acetate)
Similar products	1470374-22-1
Available
Product Description	TAK-448 acetate (MVT-602 acetate) is a potent and full KISS1R agonist with an IC50 of 460 pM and an EC50 of 632 pM[1].
StorageTemperature	-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Shipping	Blue Ice
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	1285.41
Clinical_Information	Phase 2
Manufacturers Research Area	Cancer
Solubility	DMSO : ≥ 100 mg/mL\|H2O : 50 mg/mL (ultrasonic)
Manufacturers Target	Kisspeptin Receptor
Pathway	GPCR/G Protein

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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HY-P0076A-5mg-safety-datasheet.pdf