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Vapreotide (acetate)

Vapreotide (acetate)

Item no.	HY-P0061A-50mg
Manufacturer	MedChem Express
CASRN	849479-74-9
Amount	50 mg
Quantity options	100 mg 10mM*1 mL 10 mg 1mg 25 mg 50 mg 5 mg
Category	Oncology Neuroscience Neuroinflammation Metabolism Diabetes Molecular Targets for Neuroscience Inhibitors & Compound Libraries Small Molecules By Organ Testicular & Prostate Cancer
Type	Inhibitors
Specific against	other
Purity	99.67
Formula	C59H74N12O11S2
Citations	[1]Spitsin S, et al. Analog of somatostatin vapreotide exhibits biological effects in vitro via interaction with neurokinin-1 receptor. Neuroimmunomodulation. 2013;20(5):247-55.<br/>[2]Hofland LJ, et al. Relative potencies of the somatostatin analogs octreotide, BIM-23014, and RC-160 on theinhibition of hormone release by cultured human endocrine tumor cells and normal rat anterior pituitary cells. Endocrinology. 1994 Jan;134(1):301-6.<br/>[3]Buscail L, et al. Inhibition of cell proliferation by the somatostatin analogue RC-160 is mediated by somatostatin receptor subtypes SSTR2 and SSTR5 through different mechanisms. Proc Natl Acad Sci U S A. 1995 Feb 28;92(5):1580-4.<br/>[4]Veal N, et al. Hemodynamic effects of acute and chronic administration of vapreotide in rats with cirrhosis. Dig Dis Sci. 2003 Jan;48(1):154-61.<br/>[5]Pinski J, et al. Effect of somatostatin analog RC-160 and bombesin/gastrin releasing peptide antagonist RC-3095 on growth of PC-3 human prostate-cancer xenografts in nude mice.
Smiles	O=C([C@@H](NC([C@H](CSSC[C@H](NC([C@@H](NC([C@@H](NC1=O)CCCCN)=O)C(C)C)=O)C(N[C@H](C(N)=O)CC2=CNC3=CC=CC=C23)=O)NC([C@H](N)CC4=CC=CC=C4)=O)=O)CC5=CC=C(C=C5)O)N[C@@H]1CC6=CNC7=CC=CC=C67.CC(O)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	RC-160 (acetate); BMY-41606 (acetate)
Available
Product Description	Vapreotide acetate (RC-160 acetate; BMY-41606 acetate) is a neurokinin-1 (NK1) receptor antagonist, with an IC50 of 330 nM.
StorageTemperature	-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Shipping	Blue Ice
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	1191.42
Clinical Information	Launched
Manufacturers Research Area	Cancer
Solubility	H2O : 14.29 mg/mL (ultrasonic)
Target	Neurokinin Receptor
Manufacturers Target	Neurokinin Receptor
Isoform	NK1
Manufacturers Pathway	GPCR/G Protein; Neuronal Signaling
Manufacturers Product type	Peptides

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HY-P0061A-50mg-safety-datasheet.pdf