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Sophoflavescenol

Sophoflavescenol

Item no.	HY-N2284-1mg
Manufacturer	MedChem Express
CASRN	216450-65-6
Amount	1 mg
Quantity options	1 mg 5 mg
Category	Oncology Neuroscience Molecular Targets for Neuroscience Aging & Neurological Disorders Protein Aggregation, Clearance & Misfolding Inhibitors & Compound Libraries Small Molecules By Organ Lung Cancer
Type	Inhibitors
Specific against	other
Purity	98.15
Formula	C21H20O6
Citations	[1]Jung HA, et al. Anti-tumorigenic activity of sophoflavescenol against Lewis lung carcinoma in vitro and in vivo. Arch Pharm Res. 2011 Dec;34(12):2087-99<br/>[2]Jung HA, et al. Antidiabetic complications and anti-Alzheimer activities of sophoflavescenol, a prenylated flavonol from Sophora flavescens, and its structure-activity relationship. Phytother Res. 2011 May;25(5):709-15.<br/>[3]Shin HJ, et al. A prenylated flavonol, sophoflavescenol: a potent and selective inhibitor of cGMP phosphodiesterase 5. Bioorg Med Chem Lett. 2002 Sep 2;12(17):2313-6.
Smiles	O=C1C(O)=C(C2=CC=C(O)C=C2)OC3=C(C/C=C(C)\C)C(O)=CC(OC)=C13
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	216450-65-6
Available
Product Description	Sophoflavescenol is a prenylated flavonol, which shows great inhibitory activity with IC50 of 0.013 μM against Phosphodiesterase 5 (PDE5), and also inhibits RLAR, HRAR, AGE, BACE1, AChE and BChE with IC50s of 0.30 µM, 0.17 µM, 17.89 µg/mL, 10.98 µM, 8.37 µM and 8.21 µM, respectively.
StorageTemperature	4°C (Powder, sealed storage, away from moisture and light)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	368.38
Clinical Information	No Development Reported
Manufacturers Research Area	Cancer
Solubility	DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)
Target	Beta-secretase; Cholinesterase (ChE); Phosphodiesterase (PDE)
Manufacturers Target	Beta-secretase; Cholinesterase (ChE); Phosphodiesterase (PDE)
Isoform	AChE; BACE1; BChE; PDE5
Manufacturers Pathway	Metabolic Enzyme/Protease; Neuronal Signaling
Manufacturers Product type	Natural Products

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HY-N2284-1mg-safety-datasheet.pdf