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Cucurbitacin D

Cucurbitacin D

Item no.	HY-N1986-10mg
Manufacturer	MedChem Express
CASRN	3877-86-9
Amount	10 mg
Quantity options	10mM/1mL 10 mg 1 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.91
Formula	C30H44O7
Citations	[1]Hall JA, et al. Cucurbitacin D Is a Disruptor of the HSP90 Chaperone Machinery. J Nat Prod. 2015 Apr 24;78(4):873-9.
Smiles	C[C@@]([C@@](CC=C(C(C)1C)[C@@]2([H])C[C@H](O)C1=O)([H])[C@@]2(C)C3=O)(C[C@@H](O)[C@]4([H])[C@@](C)(O)C(/C=C/C(C)(O)C)=O)[C@@]4(C3)C
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	3877-86-9
Available
Product Description	Cucurbitacin D is an active component in Trichosanthes kirilowii, disrupts interactions between Hsp90 and two co-chaperones, Cdc37 and p23. Cucurbitacin D prevents Hsp90 client (Her2, Raf, Cdk6, pAkt) maturation without induction of the heat shock response. Anti-cancer activity[1][1].
StorageTemperature	4°C (Powder, protect from light)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	516.67
Clinical Information	No Development Reported
Manufacturers Research Area	Cancer
Solubility	DMSO : 110 mg/mL (ultrasonic)
Target	HSP
Manufacturers Target	HSP
Isoform	HSP90
Manufacturers Pathway	Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Manufacturers Product type	Natural Products

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HY-N1986-10mg-safety-datasheet.pdf