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Dihydroberberine

Dihydroberberine

Manufacturer	MedChem Express
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Amount	10 mg
Quantity options	10 mg 1mg 20mg 25 mg 5 mg
Item no.	HY-N1934-10mg
CASRN	483-15-8
eClass 6.1	30220300
eClass 9.0	32160605
Available
Alias	483-15-8
Purity	98.44
Product Description	Dihydroberberine is a naturally occurring isoquinoline alkaloid with anti-inflammatory, anti-atherosclerotic, hypolipidemic and anti-tumor activities. Dihydroberberine inhibits the human ether-related gene (hERG) channel and significantly reduces the expression of heat shock protein 90 (Hsp90) and its interaction with hERG. Dihydroberberine also blocks the TLR4/MyD88/NF-κB signaling pathway to reduce pro-inflammatory cytokines and immunoglobulins, and has inhibitory effects on DSS (HY-116282C)-induced experimental colitis. Dihydroberberine also increases the sensitivity of lung cancer to sunitinib (HY-10255A), with synergistic efficacy[1][2].
StorageTemperature	4°C (Powder, sealed storage, away from moisture and light)
Shipping	Room Temperature
Manufacturers Applications	COVID-19-anti-virus
MolecularWeight	337.37
Clinical_Information	No Development Reported
Manufacturers Research Area	Cancer; Inflammation/Immunology; Cardiovascular Disease
Solubility	DMSO : 20 mg/mL (ultrasonic; warming; heat to 70°C)
Manufacturers Target	HSP; Potassium Channel
Isoform	HSP90
Pathway	Cell Cycle/DNA Damage; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease

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