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Loureirin B

Loureirin B

Item no.	HY-N1504-5mg
Manufacturer	MedChem Express
CASRN	119425-90-0
Amount	5 mg
Quantity options	10 mM/1 mL 10 mg 1 mg 5 mg
Category	Oncology Food Safety Proteins Neuroscience Neural Lineage Markers Metabolism Diabetes Cholesterol & Lipid Metabolism Regulation of Appetite Neural Signaling Inhibitors & Compound Libraries Small Molecules By Organ Skin Cancer Colorectal Cancer Breast Cancer Neurodegeneration Markers
Type	Inhibitors
Specific against	other
Purity	99.16
Formula	C18H20O5
Citations	[1]Sha Y, et al. Loureirin B promotes insulin secretion through inhibition of KATP channel and influx of intracellular calcium. J Cell Biochem. 2017 Aug 17. [2]He T, et al. Loureirin B Inhibits Hypertrophic Scar Formation via Inhibition of the TGF-β1-ERK/JNK Pathway. Cell Physiol Biochem. 2015;37(2):666-76. [3]Bai X, et al. Loureirin B inhibits fibroblast proliferation and extracellular matrix deposition in hypertrophic scar via TGF-β/Smad pathway. Exp Dermatol. 2015 May;24(5):355-60. [4]Yu Jiang, et al. Bioactivity-Guided Fractionation of the Traditional Chinese Medicine Resina Draconis Reveals Loureirin B as a PAI-1 Inhibitor. Evidence-Based Complementary and Alternative Medicine
Smiles	O=C(C1=CC=C(O)C=C1)CCC2=C(OC)C=C(OC)C=C2OC
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	119425-90-0
Shipping condition	Room temperature
Available
Manufacturer - Type	Natural Products
Manufacturer - Applications	Metabolism-protein/nucleotide metabolism
Manufacturer - Targets	ERK; JNK; PAI-1; Potassium Channel
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	316.35
Product Description	Loureirin B, a flavonoid extracted from Dracaena cochinchinensis, is an inhibitor of plasminogen activator inhibitor-1 (PAI-1), with an IC50 of 26.10?μM; Loureirin B also inhibits KATP, the phosphorylation of ERK and JNK, and has anti-diabetic activity.
Manufacturer - Research Area	Metabolic Disease
Solubility	DMSO : ≥ 150 mg/mL
Manufacturer - Pathway	MAPK/ERK Pathway; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Stem Cell/Wnt
Isoform	ERK; JNK
Clinical information	No Development Reported

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HY-N1504-5mg-safety-datasheet.pdf