Fraxin

Item no.	HY-N0579-10mg
Manufacturer	MedChem Express
CASRN	524-30-1
Amount	10 mg
Quantity options	10mM/1mL 10 mg 1 mg 25 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.83
Formula	C16H18O10
Citations	[1]Fraxin (50 mg/kg, p.o.) significantly blocks the CCl<sub>4</sub>-induced elevation of ALT and AST. Fraxin (10 and 50 mg/kg, p.o.) significantly reduces the GSSG levels (1.7±0.3 and 1.5±0.2 nM/g liver, respectively) compared with the GSSG levels of the CCl<sub>4</sub>-treated group<sup>[1]</sup>.<br/>[2]Whang WK, et al. Natural compounds,fraxin and chemicals structurally related to fraxin protect cells from oxidative stress. Exp Mol Med. 2005 Oct 31;37(5):436-46.
Smiles	OC1=C(OC)C=C(C=C2)C(OC2=O)=C1O[C@@H]([C@@H]([C@@H](O)[C@@H]3O)O)O[C@@H]3CO
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Fraxoside
Available
Product Description	Fraxin isolated from Cortex Fraxini, is a glucoside of fraxetin and reported to exert potent anti-oxidative stress action[1], anti-inflammatory and antimetastatic properties. Fraxin shows its antioxidative effect through inhibition of cyclo AMP phosphodiesterase enzyme[2].
StorageTemperature	4°C (Powder, protect from light)
Shipping	Room Temperature
Manufacturers Applications	COVID-19-immunoregulation
MolecularWeight	370.31
Clinical Information	Phase 1
Manufacturers Research Area	Inflammation/Immunology
Solubility	DMSO : 250 mg/mL (ultrasonic)
Target	Phosphodiesterase (PDE)
Manufacturers Target	Phosphodiesterase (PDE)
Manufacturers Pathway	Metabolic Enzyme/Protease
Manufacturers Product type	Natural Products

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HY-N0579-10mg-safety-datasheet.pdf