Item no. |
HY-N0527-10mM |
Manufacturer |
MedChem Express
|
CASRN |
14937-32-7 |
Amount |
10mM/1mL |
Quantity options |
100 mg
10mM/1mL
10 mg
1 mg
50 mg
5 mg
|
Category |
|
Type |
Inhibitors |
Specific against |
other |
Purity |
99.77 |
Formula |
C41H32O26 |
Citations |
[1]Zeng J, et al. Pentagalloylglucose disrupts the PALB2-BRCA2 interaction and potentiates tumor sensitivity to PARP inhibitor and radiotherapy. Cancer Lett. 2022 Oct 10;546:215851. <br/>[2]Tong J, et al. Pentagalloylglucose reduces AGE-induced inflammation by activating Nrf2/HO-1 and inhibiting the JAK2/STAT3 pathway in mesangial cells. J Pharmacol Sci. 2021 Dec;147(4):305-314. <br/>[3]Fan CW, et al. Pentagalloylglucose suppresses the growth and migration of human nasopharyngeal cancer cells via the GSK3β/β-catenin pathway in vitro and in vivo. Phytomedicine. 2022 Jul 20;102:154192. <br/>[4]Viswanatha GL, et al. Alleviation of transient global ischemia/reperfusion-induced brain injury in rats with 1,2,3,4,6-penta-O-galloyl-β-d-glucopyranose isolated from Mangifera indica. Eur J Pharmacol. 2013 Nov 15;720(1-3):286-93. <br/>[5]Kim YH, et al. 1,2,3,4,6-penta-O-galloyl-β-D-glucopyranose increases a population of T regulatory cells and inhibits IgE production in ovalbumin-sensitized mice. Int Immunopharmacol. 2015 May;26(1):30-6. |
Smiles |
O=C(C1=CC(O)=C(O)C(O)=C1)O[C@@H]([C@@H]([C@@H](COC(C2=CC(O)=C(O)C(O)=C2)=O)O3)OC(C4=CC(O)=C(O)C(O)=C4)=O)[C@H]([C@@H]3OC(C5=CC(O)=C(O)C(O)=C5)=O)OC(C6=CC(O)=C(O)C(O)=C6)=O |
ECLASS 10.1 |
32160490 |
ECLASS 11.0 |
32160490 |
UNSPSC |
12000000 |
Alias |
Penta-O-galloyl-β-D-glucose; 1,2,3,4,6-Pentagalloyl glucose |
Available |
|
Product Description |
Pentagalloylglucose (Penta-O-galloyl-β-D-glucose) is an orally active gallic tannin compound with antioxidant, anti mutagenic, anti-inflammatory, anticonvulsant, cardioprotective, anti allergic, cholesterolemic, and anti-tumor activities[1][2][3]. |
StorageTemperature |
-20°C, 3 years; 4°C, 2 years (Powder) |
Shipping |
Room Temperature |
MolecularWeight |
940.68 |
Clinical Information |
No Development Reported |
Manufacturers Research Area |
Cancer; Infection; Inflammation/Immunology; Neurological Disease |
Solubility |
DMSO : 100 mg/mL (ultrasonic)|H2O : 6 mg/mL (ultrasonic; warming) |
Target |
Apoptosis; JAK; Keap1-Nrf2; Reactive Oxygen Species; β-catenin |
Manufacturers Target |
Apoptosis; JAK; Keap1-Nrf2; Reactive Oxygen Species; β-catenin |
Manufacturers Pathway |
Apoptosis; Epigenetics; Immunology/Inflammation; JAK/STAT Signaling; Metabolic Enzyme/Protease; NF-κB; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt |
Manufacturers Product type |
Natural Products |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.