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Vincristine (sulfate)

Vincristine (sulfate)

Item no.	HY-N0488-10mg
Manufacturer	MedChem Express
CASRN	2068-78-2
Amount	10 mg
Quantity options	100 mg 10mM/1mL 10 mg 200 mg 50 mg 5 mg
Category	Oncology Inhibitors & Compound Libraries Small Molecules By Organ Colorectal Cancer Heart & Blood Cancer Lymphatic System Cancer
Type	Inhibitors
Specific against	other
Purity	99.81
Formula	C46H58N4O14S
Citations	Acta Pharmacol Sin. 2021 Jan;42(1):108-114.<br>Am J Cancer Res. 2021 Apr 15;11(4):1428-1445.<br>bioRxiv. 2023 Jul 25.<br>bioRxiv. 2023 Jun 3.<br>bioRxiv. 2023 Sep 16.<br>Cancer Immunol Res. 2023 May 3;11(5):583-599.<br>Cancers (Basel). 2021, 13(13), 3323.<br>Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8.<br>Cell Rep Med. 2024 Mar 19;5(3):101468.<br>Cell. 2024 Apr 25;187(9):2288-2304.e27.<br>Eur J Med Chem. 2018 Feb 25;146:157-170.<br>Front Microbiol. 2019 May 9;10:939. <br>Front Oncol. 2021 Apr 22;11:665763.<br>Front Oncol. 2021 Apr 6.<br>Hum Exp Toxicol. 2021 Feb 4;960327121991901.<br>Int J Biol Macromol. 2019 Jan 30;128:574-582.<br>Int J Nanomedicine. 2017 Mar 16;12:2081-2108.<br>J Chromatogr B. 2021, 122591.<br>J Clin Invest. 2024 Mar 7:e172716.<br>Leuk Lymphoma. 2020 Feb;61(2):420-428.<br>Leukemia. 2021 Mar 29.<br>Mol Ther. 2021 Jul 1;S1525-0016(21)00353-1.<br>Neurobiol Learn Mem. 2019 Sep;163:107038.<br>Oncotarget. 2017 Dec 2;8(68):112313-112329.<br>Pharmacol Res. 2024 May 9:204:107208.<br>Sci Adv. 2023 Feb 10;9(6):eade9238.<br>Sci Rep. 2019 Aug 12;9(1):11677.<br>SLAS Discov. 2024 Feb 12;29(2):100147.<br>Biochem Biophys Res Commun. 2023 Jun 27;674:27-35.<br>Biomed Pharmacother. 2020 May;125:110003.<br>bioRxiv. 2023 Apr 14.<br>bioRxiv. 2023 Feb 27.<br>bioRxiv. 2019 Dec.<br>Breast Cancer Res Treat. 2023 May 19.<br>Cancers (Basel). 2022 Oct 19;14(20):5127.<br>Cell Mol Immunol. 2023 Jan;20(1):51-64.<br>DRUG RESIST UPDATE. 2023 Feb 13;68:100951.<br>Front Oncol. 2020 Mar 13;10:308.<br>Front Pharmacol. 15 July 2022.<br>J Biomed Inform. 2023 May 15;104383.<br>J Transl Med. 2023 Jan 9;21(1):9.<br>Mol Pharm. 2022 Oct 21.<br>[1]Gidding, C.E., et al, Vincristine revisited. Crit Rev Oncol Hematol, 1999. 29(3): p. 267-87.<br>[2]Jordan, M.A., et al. Comparison of the effects of vinblastine, vincristine, vindesine, and vinepidine on microtubule dynamics and cell proliferation in vitro. Cancer Res, 1985. 45(6): p. 2741-7.<br>[3]Baguley, B.C., et al, Inhibition of growth of colon 38 adenocarcinoma by vinblastine and colchicine: evidence for a vascular mechanism. Eur J Cancer, 1991. 27(4): p. 482-7.<br>[4]Zhang D, et al. Co-delivery nanoparticles with characteristics of intracellular precision release drugs for overcoming multidrug resistance. Int J Nanomedicine. 2017 Mar 16;12:2081-2108.<br>[5]Donoso, J.A., et al, Action of the vinca alkaloids vincristine, vinblastine, and desacetyl vinblastine amide on axonal fibrillar organelles in vitro. Cancer Res, 1977. 37(5): p. 1401-7.<br>[6]Horton, J.K., et al. Relationships between tumor responsiveness, vincristine pharmacokinetics and arrest of mitosis in human tumor xenografts. Biochem Pharmacol, 1988. 37(20): p. 3995-4000.
Smiles	CC[C@@]1(C=CCN2CC3)[C@@]2([H])[C@@]3(C4=CC([C@](C5=C6C7=CC=CC=C7N5)(C[C@](C[C@](CC)(O)C8)([H])C[N@@]8CC6)C(OC)=O)=C(OC)C=C4N9C=O)[C@]9([H])[C@](C(OC)=O)(O)[C@@H]1OC(C)=O.O=S(O)(O)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Leurocristine (sulfate); NSC-67574 (sulfate); 22-Oxovincaleukoblastine (sulfate)
Available
Product Description	Vincristine sulfate is an antitumor vinca alkaloid which inhibits microtubule formation in mitotic spindle, resulting in an arrest of dividing cells at the metaphase stage. It binds to microtubule with a Ki of 85 nM.
StorageTemperature	4°C (Powder, sealed storage, away from moisture and light)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	923.04
Clinical_Information	Launched
Manufacturers Research Area	Cancer
Solubility	DMSO : 83.33 mg/mL (ultrasonic; warming; heat to 80°C)\|H2O : 50 mg/mL (ultrasonic)
Manufacturers Target	Apoptosis; Microtubule/Tubulin
Pathway	Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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HY-N0488-10mg-safety-datasheet.pdf