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Cholesterol

Cholesterol

Item no.	HY-N0322-500mg
Manufacturer	MedChem Express
CASRN	57-88-5
Amount	500 mg
Category	Food Safety Other Parameters Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Clone	N/A
Specific against	other
Purity	99.94
Formula	C27H46O
Citations	Antiviral Res. 2022 Dec 15;209:105497.<br>Biochem Biophys Res Commun. 2020 Feb 19;522(4):862-868.<br>iScience. 2024 Apr 3.<br>J Nanobiotechnology. 2022 Oct 20;20(1):454.<br>J Pharm Sci. 2024 May 25:S0022-3549(24)00199-0.<br>Life Sci Alliance. 2022 Jan 4;5(3):e202101256.<br>Life Sci. 2023 Apr 18;121698.<br>Nanomedicine. 2024 Mar 16:102745.<br>Nat Chem Biol. 2022 Aug 18.<br>Nat Commun. 2024 Jan 2;15(1):162.<br>Nat Nanotechnol. 2021 Oct;16(10):1150-1160.<br>Patent. US20200376102A1.<br>Patent. US20200376146A1.<br>Phytomedicine. 2024 Jan 20, 155299.<br>Polym Test. 2023 Dec 1, 108292.<br>Redox Biol. 2023 Jun.<br>Sci China Life Sci. 2021 May 27;1-21.<br>SSRN. 2024 Feb 5.<br>Theranostics. 2021 Jan 1;11(2):841-860.<br>Vet Microbiol. 2024 Jan, 288, 109948.<br>Viruses. 2022, 14(3), 514.<br>Adv Sci (Weinh). 2023 Sep;10(27):e2206878.<br>Immunity. 2024 Apr 12:S1074-7613(24)00142-0.<br>[1]Casaburi I, et al. Cholesterol as an Endogenous ERRα Agonist: A New Perspective to Cancer Treatment. Front Endocrinol (Lausanne). 2018 Sep 11;9:525.<br>[2]Dietschy JM, et al. Thematic review series: brain Lipids. Cholesterol metabolism in the central nervous system during early development and in the mature animal. J Lipid Res. 2004 Aug;45(8):1375-97.<br>[3]Fukui K, et al. Effect of Cholesterol Reduction on Receptor Signaling in Neurons. J Biol Chem. 2015 Sep 14.
Smiles	O[C@H](C1)CC[C@@]2(C)C1=CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@]4([H])[C@@H](CCCC(C)C)C
ECLASS 5.1	30220300
ECLASS 6.1	30220300
ECLASS 8.0	32160605
ECLASS 9.0	32160605
ECLASS 10.0.1	32160490
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	57-88-5
Available
Product Description	Cholesterol is the major sterol in mammals. It is making up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins[1][2]. Cholesterol is also an endogenous estrogen-related receptor α (ERRα) agonist[3].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
MolecularWeight	386.65
Clinical_Information	Launched
Manufacturers Research Area	Metabolic Disease; Cancer
Solubility	DMSO : < 1 mg/mL (ultrasonic; warming; heat to 60°C)\|Ethanol : 20 mg/mL (ultrasonic)
Manufacturers Target	Bacterial; Endogenous Metabolite; Estrogen Receptor/ERR; Liposome
Isoform	Human Endogenous Metabolite; Microbial Metabolite
Pathway	Anti-infection; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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HY-N0322-500mg-safety-datasheet.pdf