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Saikosaponin D

Saikosaponin D

Item no.	HY-N0250-100mg
Manufacturer	MedChem Express
CASRN	20874-52-6
Amount	100 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 1 mg 25 mg 50 mg 5 mg
Category	Food Safety Hormones Neuroscience Neural Lineage Markers Metabolism Diabetes Glucose Homeostasis Neural Transcription Factors Neural Signaling Neural Adhesion Molecules Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	98.76
Formula	C42H68O13
Citations	[1]Jang MJ, et al. Saikosaponin D isolated from Bupleurum falcatum inhibits selectin-mediated cell adhesion. Molecules. 2014 Dec 4;19(12):20340-9. [2]Liu A, et al. Saikosaponin d protects against acetaminophen-induced hepatotoxicity by inhibiting NF-κB and STAT3 signaling. Chem Biol Interact. 2014 Nov 5;223:80-6. [3]Que R, et al. Estrogen receptor-β-dependent effects of saikosaponin‑d on the suppression of oxidative stress-induced rat hepatic stellate cell activation. Int J Mol Med. 2018 Mar;41(3):1357-1364.
Smiles	CC1(C)CC[C@]2(CO3)[C@H](O)C[C@@]4(C)[C@]([C@]5([H])C=C[C@]43[C@]2([H])C1)(C)CC[C@@]([C@]5(C)CC6)([H])[C@@](CO)(C)[C@H]6O[C@@](O[C@H](C)[C@@H]7O)([H])[C@H](O)[C@H]7O[C@@]8([H])[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O8
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	20874-52-6
Shipping condition	Room temperature
Available
Manufacturer - Type	Natural Products
Manufacturer - Applications	Cancer-Kinase/protease
Manufacturer - Targets	Bacterial; Estrogen Receptor/ERR; NF-κB; STAT
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	780.98
Product Description	Saikosaponin D is a triterpene saponin isolated from Bupleurum, with anti-inflammatory, anti-bacterial, anti-tumor, and anti-allergic activities; Saikosaponin D inhibits selectin, STAT3 and NF-kB and activates estrogen receptor-β.
Manufacturer - Research Area	Cancer; Infection; Inflammation/Immunology
Solubility	DMSO : 50 mg/mL (ultrasonic)\|H2O : 1 mg/mL (ultrasonic; warming; heat to 60°C)
Manufacturer - Pathway	Anti-infection; JAK/STAT Signaling; NF-κB; Stem Cell/Wnt; Vitamin D Related/Nuclear Receptor
Isoform	ERβ; NF-κB; STAT3
Clinical information	No Development Reported

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HY-N0250-100mg-safety-datasheet.pdf