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(S)-10-Hydroxycamptothecin

(S)-10-Hydroxycamptothecin

Item no.	HY-N0095-50mg
Manufacturer	MedChem Express
CASRN	19685-09-7
Amount	50 mg
Quantity options	100 mg 10mM/1mL 50 mg
Category	Oncology Inhibitors & Compound Libraries Small Molecules By Organ Lung Cancer
Type	Inhibitors
Specific against	other
Purity	99.38
Formula	C20H16N2O5
Citations	[1]Min Liu, et al. Intracellular delivery of 10-hydroxycamptothecin <br>with targeted nanostructured lipid carriers against <br>multidrug resistance . Journal of Drug Targeting.<br/>[2]Min Liu, et al. Intracellular delivery of 10-hydroxycamptothecin with targeted <br>nanostructured lipid carriers against multidrug resistance. J Drug Target, Early Online: 1–8<br/>[3]Yu P, et al. Synthesis and preliminary anticancer evaluation of 10-hydroxycamptothecin analogs. Biol Pharm Bull. 2012;35(8):1295-9.<br/>[4]Zhang XW, et al. Differentiation-inducing action of 10-hydroxycamptothecin on human hepatoma Hep G2 cells. Acta Pharmacol Sin. 2000 Apr;21(4):364-8.<br/>[5]Zhang XW, et al. Differential regulation of P53, c-Myc, Bcl-2, Bax and AFP protein expression, and caspase activity during 10-hydroxycamptothecin-induced apoptosis in Hep G2 cells. Anticancer Drugs. 2000 Oct;11(9):747-56.<br/>[6]Liu M, et al. Intracellular delivery of 10-hydroxycamptothecin with targeted nanostructured lipid carriers against multidrug resistance. J Drug Target. 2016;24(5):433-40.
Smiles	O=C1[C@](O)(CC)C2=C(CO1)C(N3CC4=CC5=CC(O)=CC=C5N=C4C3=C2)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	10-HCPT; 10-Hydroxycamptothecin
Available
Product Description	(S)-10-Hydroxycamptothecin (10-HCPT; 10-Hydroxycamptothecin) is a DNA topoisomerase I inhibitor of isolated from the Chinese plant Camptotheca accuminata. (S)-10-Hydroxycamptothecin exhibits a remarkable apoptosis-inducing effect. (S)-10-Hydroxycamptothecin has the potential for hepatoma, gastric carcinoma, colon cancer and leukaemia treatment[1][2][3][4].
StorageTemperature	4°C (Powder, protect from light)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	364.35
Clinical Information	Phase 2
Manufacturers Research Area	Cancer
Solubility	DMSO : 50 mg/mL (ultrasonic)
Target	Apoptosis; Topoisomerase
Manufacturers Target	Apoptosis; Topoisomerase
Isoform	Topo I
Manufacturers Pathway	Apoptosis; Cell Cycle/DNA Damage
Manufacturers Product type	Natural Products

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HY-N0095-50mg-safety-datasheet.pdf