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N-Acetylneuraminic acid

N-Acetylneuraminic acid

Item no.	HY-I0400-1g
Manufacturer	MedChem Express
CASRN	131-48-6
Amount	1 g
Quantity options	100 mg 10mM/1mL 1 g
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.44
Formula	C11H19NO9
Citations	[1]Kiefel MJ, et al. Synthesis and biological evaluation of N-acetylneuraminic acid-based rotavirus inhibitors[J]. J Med Chem. 1996 Mar 15;39(6):1314-20.<br/>[2]Yoshikawa, K., et al. N-Acetylneuraminic Acid Inhibits Melanogenesis via Induction of Autophagy[J]. Cosmetics 2024, 11, 82.<br/>[3]Zhang L, et al. Functional Metabolomics Characterizes a Key Role for N-Acetylneuraminic Acid in Coronary Artery Diseases[J]. Circulation. 2018 Mar 27;137(13):1374-1390.
Smiles	OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](NC(C)=O)[C@@H](O)CC(C(O)=O)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	NANA; Lactaminic acid
Available
Product Description	N-Acetylneuraminic acid (NANA; Lactaminic acid), a nonphenolic structure, is the predominant form of sialic from Collocalia esculenta. N-Acetylneuraminic acid plays a biological role in myocardial injury, melanoma and viral or bacterial infection. N-Acetylneuraminic acid inhibits melanogenesis by reducing tyrosinase activity and triggers myocardial injury in vitro and in vivo by activation of the Rho/Rho-associated signaling pathway through binding to RhoA and Cdc42, which is promising for research in the field of melanoma and coronary artery diseases[1][2][3].
StorageTemperature	-20°C (Powder, stored under nitrogen)
Shipping	Blue Ice
Manufacturers Applications	COVID-19-anti-virus
MolecularWeight	309.27
Clinical Information	Phase 1
Manufacturers Research Area	Cancer; Inflammation/Immunology; Cardiovascular Disease
Solubility	H2O : ≥ 125 mg/mL
Target	Endogenous Metabolite; Influenza Virus; Ras; Tyrosinase
Manufacturers Target	Endogenous Metabolite; Influenza Virus; Ras; Tyrosinase
Isoform	Human Endogenous Metabolite; Microbial Metabolite
Manufacturers Pathway	Anti-infection; GPCR/G Protein; MAPK/ERK Pathway; Metabolic Enzyme/Protease
Manufacturers Product type	Natural Products

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HY-I0400-1g-safety-datasheet.pdf