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Diaveridine

Diaveridine

Item no.	HY-B1902-5g
Manufacturer	MedChem Express
CASRN	5355-16-8
Amount	5g
Quantity options	10mM/1mL 1 g 250 mg 5g
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.79
Citations	[1]Sirichaiwat C et al. Target guided synthesis of 5-benzyl-2,4-diamonopyrimidines: their antimalarial activities and binding affinities to wild type and mutant dihydrofolate reductases from Plasmodium falciparum. J Med Chem 47:345-54 (2004).<br/>[2]Ono T, et al. The genotoxicity of diaveridine and trimethoprim. Environ Toxicol Pharmacol. 1997 Sep;3(4):297-306.<br/>[3]Wang J, et al. Acute, mutagenicity, teratogenicity and subchronic oral toxicity studies of diaveridine in rodents. Environ Toxicol Pharmacol. 2015 Sep;40(2):660-70.
Smiles	NC1=NC=C(CC2=CC=C(OC)C(OC)=C2)C(N)=N1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	EGIS-5645
Available
Product Description	Diaveridine (EGIS-5645) is a dihydrofolate reductase (DHFR) inhibitor with a Ki of 11.5 nM for the wild type DHFR and also an antibacterial agent.
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	COVID-19-anti-virus
MolecularWeight	260.29
Clinical Information	No Development Reported
Manufacturers Research Area	Infection
Solubility	DMSO : 33.33 mg/mL (ultrasonic)
Target	Antifolate; Bacterial
Manufacturers Target	Antifolate; Bacterial
Manufacturers Pathway	Anti-infection; Cell Cycle/DNA Damage
Manufacturers Product type	Reference compound

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HY-B1902-5g-safety-datasheet.pdf