Item no. |
HY-B1751-10mM |
Manufacturer |
MedChem Express
|
CASRN |
56-54-2 |
Amount |
10mM/1mL |
Quantity options |
100 mg
10mM/1mL
|
Category |
|
Type |
Inhibitors |
Specific against |
other |
Purity |
99.80 |
Formula |
C20H24N2O2 |
Citations |
[1]Kehl SJ, et al. Quinidine-induced inhibition of the fast transient outward K+ current in rat melanotrophs. Br J Pharmacol. 1991 Jul;103(3):1807-13.<br/>[2]Roden DM, et al. Class I antiarrhythmic agents: quinidine, procainamide and N-acetylprocainamide, disopyramide.<br/>[3]Sang-Yun Lee, et al. Hydrocinchonine, cinchonine, and quinidine potentiate paclitaxel-induced cytotoxicity and apoptosis via multidrug resistance reversal in MES-SA/DX5 uterine sarcoma cells. Environ Toxicol. 2011 Aug;26(4):424-31.<br/>[4]Hassan Jamali, et al. Effect of dextromethorphan/quinidine on pentylenetetrazole- induced clonic and tonic seizure thresholds in mice. Neurosci Lett. 2020 Jun 11;729:134988.<br/>[5]Moody DE, et al. Quinidine inhibits in vivo metabolism of amphetamine in rats: impact upon correlation between GC/MS and immunoassay findings in rat urine. J Anal Toxicol. 1990 Sep-Oct;14(5):311-7. |
Smiles |
C=C[C@H]1C[N@](CC[C@H]1C2)[C@@]2([H])[C@@H](O)C3=CC=NC4=CC=C(OC)C=C34 |
ECLASS 10.1 |
32160490 |
ECLASS 11.0 |
32160490 |
UNSPSC |
12000000 |
Alias |
56-54-2 |
Available |
|
Product Description |
Quinidine (15% dihydroquinidine) is an antiarrhythmic agent. Quinidine is a potent, orally active, selective cytochrome P450db inhibitor. Quinidine is also a K+ channel blocker with an IC50 of 19.9 μM, and can induce apoptosis. Quinidine can be used for malaria research[1][2][3][4]. |
StorageTemperature |
4°C (Powder, protect from light, stored under nitrogen) |
Shipping |
Room Temperature |
Manufacturers Applications |
COVID-19-immunoregulation |
MolecularWeight |
324.42 |
Clinical Information |
Launched |
Manufacturers Research Area |
Cancer; Infection; Cardiovascular Disease |
Solubility |
DMSO : ≥ 50 mg/mL|Ethanol : 14.29 mg/mL (ultrasonic; warming; heat to 60°C)|H2O : < 0.1 mg/mL |
Target |
Apoptosis; Cytochrome P450; Parasite; Potassium Channel |
Manufacturers Target |
Apoptosis; Cytochrome P450; Parasite; Potassium Channel |
Isoform |
Plasmodium |
Manufacturers Pathway |
Anti-infection; Apoptosis; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease |
Manufacturers Product type |
Natural Products |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.