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Quinidine (15% dihydroquinidine)

Quinidine (15% dihydroquinidine)

Item no.	HY-B1751-100mg
Manufacturer	MedChem Express
CASRN	56-54-2
Amount	100 mg
Quantity options	100 mg 10mM/1mL
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.80
Formula	C20H24N2O2
Citations	[1]Kehl SJ, et al. Quinidine-induced inhibition of the fast transient outward K+ current in rat melanotrophs. Br J Pharmacol. 1991 Jul;103(3):1807-13.<br/>[2]Roden DM, et al. Class I antiarrhythmic agents: quinidine, procainamide and N-acetylprocainamide, disopyramide.<br/>[3]Sang-Yun Lee, et al. Hydrocinchonine, cinchonine, and quinidine potentiate paclitaxel-induced cytotoxicity and apoptosis via multidrug resistance reversal in MES-SA/DX5 uterine sarcoma cells. Environ Toxicol. 2011 Aug;26(4):424-31.<br/>[4]Hassan Jamali, et al. Effect of dextromethorphan/quinidine on pentylenetetrazole- induced clonic and tonic seizure thresholds in mice. Neurosci Lett. 2020 Jun 11;729:134988.<br/>[5]Moody DE, et al. Quinidine inhibits in vivo metabolism of amphetamine in rats: impact upon correlation between GC/MS and immunoassay findings in rat urine. J Anal Toxicol. 1990 Sep-Oct;14(5):311-7.
Smiles	C=C[C@H]1C[N@](CC[C@H]1C2)[C@@]2([H])[C@@H](O)C3=CC=NC4=CC=C(OC)C=C34
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	56-54-2
Available
Product Description	Quinidine (15% dihydroquinidine) is an antiarrhythmic agent. Quinidine is a potent, orally active, selective cytochrome P450db inhibitor. Quinidine is also a K+ channel blocker with an IC50 of 19.9 μM, and can induce apoptosis. Quinidine can be used for malaria research[1][2][3][4].
StorageTemperature	4°C (Powder, protect from light, stored under nitrogen)
Shipping	Room Temperature
Manufacturers Applications	COVID-19-immunoregulation
MolecularWeight	324.42
Clinical Information	Launched
Manufacturers Research Area	Cancer; Infection; Cardiovascular Disease
Solubility	DMSO : ≥ 50 mg/mL\|Ethanol : 14.29 mg/mL (ultrasonic; warming; heat to 60°C)\|H2O : < 0.1 mg/mL
Target	Apoptosis; Cytochrome P450; Parasite; Potassium Channel
Manufacturers Target	Apoptosis; Cytochrome P450; Parasite; Potassium Channel
Isoform	Plasmodium
Manufacturers Pathway	Anti-infection; Apoptosis; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease
Manufacturers Product type	Natural Products

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HY-B1751-100mg-safety-datasheet.pdf