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Pralidoxime (chloride)

Pralidoxime (chloride)

Item no.	HY-B1200-10mM
Manufacturer	MedChem Express
CASRN	51-15-0
Amount	10 mM/1 mL
Quantity options	100 mg 10 mM/1 mL
Category	Food Safety Drugs Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Clone	N/A
Specific against	other
Purity	99.73
Formula	C7H9ClN2O
Citations	[1]Cadieux CL, et al. Probing the activity of a non-oxime reactivator for acetylcholinesterase inhibited by organophosphorus nerve agents. Chem Biol Interact. 2016;259(Pt B):133‐141. [2]Eyer P, Buckley N. Pralidoxime for organophosphate poisoning. Lancet. 2006;368(9553):2110‐2111. [3]Houzé P, et al. High Dose of Pralidoxime Reverses Paraoxon-Induced Respiratory Toxicity in Mice. Turk J Anaesthesiol Reanim. 2018;46(2):131‐138.
Smiles	C[N+]1=CC=CC=C1/C=N/O.[Cl-]
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	2-PAM chloride
Shipping condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Neuroscience-Neuromodulation
Manufacturer - Targets	Cholinesterase (ChE)
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	172.61
Product Description	Pralidoxime chloride is a potent reactivator of acetylcholinesterase (AChE). Pralidoxime chloride reactivates nerve agent-inhibited AChE via direct nucleophilic attack by the oxime moiety on the phosphorus center of the bound nerve agent. Pralidoxime chloride is an antidote for organophosphate poisoning[1][2].
Manufacturer - Research Area	Neurological Disease
Solubility	DMSO : 21.67 mg/mL (ultrasonic)\|H2O : ≥ 100 mg/mL
Manufacturer - Pathway	Neuronal Signaling
Isoform	AChE
Clinical information	Launched

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HY-B1200-10mM-safety-datasheet.pdf