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Fenoldopam (mesylate)

Fenoldopam (mesylate)

Item no.	HY-B0735A-10mM
Manufacturer	MedChem Express
CASRN	67227-57-0
Amount	10mM/1mL
Quantity options	100 mg 10mM/1mL 10 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Clone	N/A
Specific against	other
Purity	99.94
Formula	C17H20ClNO6S
Citations	Cell. 2021 Feb 18;184(4):943-956.e18.<br/>Biochem Biophys Res Commun. 18 December 2021.<br/>Biomed Pharmacother. 2021, 111500.<br/>SLAS Discov. 2020 Sep;25(8):895-905.<br/>[1]A Grenader, et al. Fenoldopam is a partial agonist at dopamine-1 (DA1) receptors in LLC-PK1 cells. J Pharmacol Exp Ther. 1991 Jul 1;258(1):193-8.<br/>[2]Yan Zheng, et al. Identification of fenoldopam as a novel LSD1 inhibitor to abrogate the proliferation of renal cell carcinoma using drug repurposing strategy. Bioorg Chem. 2021 Mar;108:104561.<br/>[3]Yuta Fujii, et al. Detection of fenoldopam-induced arteritis in rats using ex vivo / in vivo MRI. Toxicology Reports, Volume 9, 2022, Pages 1595-1602.
Smiles	OC1=C(O)C=C2C(C3=CC=C(O)C=C3)CNCCC2=C1Cl.CS(=O)(O)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Fenoldopam (methanesulfonate); SKF-82526 (mesylate)
Available
Product Description	Fenoldopam mesylate (SKF-82526) is a D1 receptor agonist and a novel lysine-specific demethylase 1 (LSD1) inhibitor (IC50=0.8974 μM). Fenoldopam mesylate shows anti-hypertensive effects, anti-cancer cell proliferation activity and can induce cells apoptosis[1][2][3].
StorageTemperature	4°C (Powder, sealed storage, away from moisture)
Shipping	Room Temperature
Manufacturers Applications	COVID-19-immunoregulation
MolecularWeight	401.86
Clinical Information	Launched
Manufacturers Research Area	Cancer; Cardiovascular Disease
Solubility	DMSO : ≥ 36 mg/mL\|H2O : 10 mg/mL (ultrasonic)
Target	Apoptosis; Dopamine Receptor
Manufacturers Target	Apoptosis; Dopamine Receptor
Manufacturers Pathway	Apoptosis; GPCR/G Protein; Neuronal Signaling
Manufacturers Product type	Reference compound

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HY-B0735A-10mM-safety-datasheet.pdf