Item no. |
HY-B0735A-10mg |
Manufacturer |
MedChem Express
|
CASRN |
67227-57-0 |
Amount |
10 mg |
Quantity options |
100 mg
10mM/1mL
10 mg
50 mg
5 mg
|
Category |
|
Type |
Inhibitors |
Clone |
N/A |
Specific against |
other |
Purity |
99.94 |
Formula |
C17H20ClNO6S |
Citations |
Cell. 2021 Feb 18;184(4):943-956.e18.<br/>Biochem Biophys Res Commun. 18 December 2021.<br/>Biomed Pharmacother. 2021, 111500.<br/>SLAS Discov. 2020 Sep;25(8):895-905.<br/>[1]A Grenader, et al. Fenoldopam is a partial agonist at dopamine-1 (DA1) receptors in LLC-PK1 cells. J Pharmacol Exp Ther. 1991 Jul 1;258(1):193-8.<br/>[2]Yan Zheng, et al. Identification of fenoldopam as a novel LSD1 inhibitor to abrogate the proliferation of renal cell carcinoma using drug repurposing strategy. Bioorg Chem. 2021 Mar;108:104561.<br/>[3]Yuta Fujii, et al. Detection of fenoldopam-induced arteritis in rats using ex vivo / in vivo MRI. Toxicology Reports, Volume 9, 2022, Pages 1595-1602. |
Smiles |
OC1=C(O)C=C2C(C3=CC=C(O)C=C3)CNCCC2=C1Cl.CS(=O)(O)=O |
ECLASS 10.1 |
32160490 |
ECLASS 11.0 |
32160490 |
UNSPSC |
12000000 |
Alias |
Fenoldopam (methanesulfonate); SKF-82526 (mesylate) |
Available |
|
Product Description |
Fenoldopam mesylate (SKF-82526) is a D1 receptor agonist and a novel lysine-specific demethylase 1 (LSD1) inhibitor (IC50=0.8974 μM). Fenoldopam mesylate shows anti-hypertensive effects, anti-cancer cell proliferation activity and can induce cells apoptosis[1][2][3]. |
StorageTemperature |
4°C (Powder, sealed storage, away from moisture) |
Shipping |
Room Temperature |
Manufacturers Applications |
COVID-19-immunoregulation |
MolecularWeight |
401.86 |
Clinical Information |
Launched |
Manufacturers Research Area |
Cancer; Cardiovascular Disease |
Solubility |
DMSO : ≥ 36 mg/mL|H2O : 10 mg/mL (ultrasonic) |
Target |
Apoptosis; Dopamine Receptor |
Manufacturers Target |
Apoptosis; Dopamine Receptor |
Manufacturers Pathway |
Apoptosis; GPCR/G Protein; Neuronal Signaling |
Manufacturers Product type |
Reference compound |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.