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Dapsone

Dapsone

Item no.	HY-B0688-1g
Manufacturer	MedChem Express
CASRN	80-08-0
Amount	1 g
Quantity options	10mM/1mL 1 g 500 mg 5 g
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Clone	N/A
Specific against	other
Purity	99.67
Formula	C12H12N2O2S
Citations	[1]D Voeller, et al. Interaction of Pneumocystis carinii dihydropteroate synthase with sulfonamides and diaminodiphenyl sulfone (dapsone).J Infect Dis. 1994 Feb;169(2):456-9.<br>[2]Esther Moreno, et al. Evaluation of Skin Permeation and Retention of Topical Dapsone in Murine Cutaneous Leishmaniasis Lesions.Pharmaceutics. 2019 Nov 13;11(11):607.<br>[3]Y I Zhu, et al. Dapsone and sulfones in dermatology: overview and update. J Am Acad Dermatol<br>[4]Dapsone, Drug.com
Smiles	O=S(C1=CC=C(N)C=C1)(C2=CC=C(N)C=C2)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	4,4′-Diaminodiphenyl sulfone; DDS
Available
Product Description	Dapsone (4, 4′-Diaminodiphenyl sulfone) is an orally active and blood-brain penetrant sulfonamide antibiotic with bacteriostatic, antimycobacterial and antiprotozoal activities[1]. Dapsone exerts effective antileprosy activity and inhibits folate synthesis in cell extracts of M. leprae. Dapsone is used for dermatologic disorder research, including leprosy, dermatitis herpetiformis, acne vulgaris et al[2][3].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	COVID-19-immunoregulation
MolecularWeight	248.30
Clinical_Information	Launched
Manufacturers Research Area	Infection; Inflammation/Immunology
Solubility	DMSO : 250 mg/mL (ultrasonic)
Manufacturers Target	Antibiotic; Bacterial; Parasite; Reactive Oxygen Species
Pathway	Anti-infection; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

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HY-B0688-1g-safety-datasheet.pdf