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Naftopidil

Naftopidil

Item no.	HY-B0391-10g
Manufacturer	MedChem Express
CASRN	57149-07-2
Amount	10 g
Quantity options	10 g 10mM/1mL 1 g 500 mg 5 g
Category	Oncology Metabolism Diabetes Glucose Homeostasis By Cell Type Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Clone	N/A
Specific against	other
Purity	98.47
Formula	C24H28N2O3
Citations	[1]Yasuhide Hori, et al. Naftopidil, a selective {alpha}1-adrenoceptor antagonist, suppresses human prostate tumor growth by altering interactions between tumor cells and stroma. Cancer Prev Res (Phila). 2011 Jan;4(1):87-96.<br>[2]R Takei, et al. Naftopidil, a novel alpha1-adrenoceptor antagonist, displays selective inhibition of canine prostatic pressure and high affinity binding to cloned human alpha1-adrenoceptors. Jpn J Pharmacol. 1999 Apr;79(4):447-54.
Smiles	OC(CN1CCN(C(C=CC=C2)=C2OC)CC1)COC3=CC=CC4=CC=CC=C34
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	KT-611; BM-15275
Available
Product Description	Naftopidil (KT-611) is is a selective alpha1-adrenoceptor antagonist, with Kis of 3.7 nM, 20 nM and 1.2 nM for the cloned human α1a-, α1b- and α1d-adrenoceptor subtypes, respectively. Naftopidil has antiproliferative effects. Naftopidil can be used for the research of prostate hyperplasia[1][2].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	COVID-19-immunoregulation
MolecularWeight	392.49
Clinical_Information	Launched
Manufacturers Research Area	Cardiovascular Disease; Endocrinology
Solubility	DMSO : 33.33 mg/mL (ultrasonic)\|H2O : < 0.1 mg/mL
Manufacturers Target	Adrenergic Receptor
Isoform	α adrenergic receptor
Pathway	GPCR/G Protein; Neuronal Signaling

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

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HY-B0391-10g-safety-datasheet.pdf