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Sulfamethizole

Sulfamethizole

Item no.	HY-B0333-10mM
Manufacturer	MedChem Express
CASRN	144-82-1
Amount	10mM/1mL
Quantity options	10mM/1mL 500 mg
Category	Oncology Food Safety Vitamines Inhibitors & Compound Libraries Small Molecules By Organ Bladder Cancer Testicular & Prostate Cancer
Type	Inhibitors
Clone	N/A
Specific against	other
Purity	99.62
Formula	C9H10N4O2S2
Citations	[1]Watanabe, H. and J.W. Hastings, Inhibition of bioluminescence in Photobacterium phosphoreum by sulfamethizole and its stimulation by thymine. Biochim Biophys Acta, 1990. 1017(3): p. 229-34.<br>[2]Kerrn, M.B., N. Frimodt-Moller, and F. Espersen, Effects of sulfamethizole and amdinocillin against Escherichia coli strains (with various susceptibilities) in an ascending urinary tract infection mouse model. Antimicrob Agents Chemother, 2003. 47(3): p. 1002-9.
Smiles	O=S(C1=CC=C(N)C=C1)(NC2=NN=C(C)S2)=O
ECLASS 5.1	30220300
ECLASS 6.1	30220300
ECLASS 8.0	32160605
ECLASS 9.0	32160605
ECLASS 10.0.1	32160490
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	144-82-1
Available
Product Description	Sulfamethizole is a sulfathiazole antibacterial agent. Target: Antibacterial Sulfamethizole is a sulfathiazole antibacterial agent. Sulfamethizole is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), a substrate of the enzyme dihydropteroate synthetase. The inhibited reaction is necessary in these organisms for the synthesis of folic acid. Sulfamethizole, an inhibitor of dihydropteroate synthetase and the formation of folic acid, inhibited bioluminescence more than growth [1]. Treatment with sulfamethizole resulted in a significant reduction in bacterial counts in all samples from a susceptible strain (MIC, 128 micro g/ml) and a resistant strain (MIC, 512 micro g/ml). Infection with a sulII gene-positive strain (MIC, >2, 048 micro g/ml) could not be treated with sulfamethizole, as no effect could be demonstrated in the urine, bladder, or kidneys [2].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	COVID-19-immunoregulation
MolecularWeight	270.33
Clinical_Information	Launched
Manufacturers Research Area	Infection
Solubility	DMSO : ≥ 100 mg/mL
Manufacturers Target	Antibiotic; Bacterial
Pathway	Anti-infection

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HY-B0333-10mM-safety-datasheet.pdf