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Chlorpheniramine (maleate)

Chlorpheniramine (maleate)

Item no.	HY-B0286A-1g
Manufacturer	MedChem Express
CASRN	113-92-8
Amount	1 g
Quantity options	100 mg 10mM/1mL 1 g 5 g
Category	Food Safety Allergenes Drugs Histamines Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Clone	N/A
Specific against	other
Purity	99.90
Formula	C20H23ClN2O4
Citations	[1]Kim J, et al. Inhibitory effects of antihistamines, diphenhydramine and chlorpheniramine, on proton currents in BV2 microglial cells. Eur J Pharmacol. 2017 Mar 5;798:122-128.<br>[2]Medina, M.A., et al., Chlorpheniramine inhibits the synthesis of ornithine decarboxylase and the proliferation of human breast cancer cell lines. Breast Cancer Res Treat, 1995. 35(2): p. 187-94.<br>[3]Kelly, J.X., et al., Design, synthesis, and evaluation of 10-N-substituted acridones as novel chemosensitizers in Plasmodium falciparum. Antimicrob Agents Chemother, 2007. 51(11): p. 4133-40.<br>[4]Iemura, R., et al., Synthesis of 2-(4-substituted-1-piperazinyl)benzimidazoles as H1-antihistaminic agents. J Med Chem, 1986. 29(7): p. 1178-83.<br>[5]Takano, N., I. Arai, and M. Kurachi, Analysis of the spontaneous scratching behavior by NC/Nga mice: a possible approach to evaluate antipruritics for subjects with atopic dermatitis. Eur J Pharmacol, 2003. 471(3): p. 223-8.
Smiles	CN(C)CCC(C1=CC=C(Cl)C=C1)C2=CC=CC=N2.O=C(O)/C=C\C(O)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Chlorphenamine maleate
Available
Product Description	Chlorpheniramine maleate is a histamine H1 receptor antagonist with an IC50 of 12 nM[1][2][3].
StorageTemperature	4°C (Powder, sealed storage, away from moisture)
Shipping	Room Temperature
Manufacturers Applications	COVID-19-immunoregulation
MolecularWeight	390.86
Clinical_Information	Launched
Manufacturers Research Area	Inflammation/Immunology; Endocrinology
Solubility	DMSO : ≥ 100 mg/mL\|H2O : 33.33 mg/mL (ultrasonic)
Manufacturers Target	Histamine Receptor
Isoform	H1 Receptor
Pathway	GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

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HY-B0286A-1g-safety-datasheet.pdf